From structure to biological intervention

While a good understanding of soluble proteins is available, our focus is the more challenging group of "insoluble" proteins for which only little structural information is available.

The mission of inSPIN is to perform structural characterization to generate knowledge that can be used systematically to design ways for biological intervention. We will generate and exploit results from structural and functional analysis to rationally design synthetic antimicrobial peptides, small molecule inhibitors for fibril formation, new contrast agents for early-stage detection of amyloid diseases, and a molecular basis for understanding extracellular matrix degradation, to name some specific targets.

We develop and apply new methods for analysis of proteins in insoluble biological structures, including membrane proteins, fibrillating proteins, and extracellular matrix proteins. These proteins consitute about half the proteome of any cell and are involved in essentially biological functions.

inSPIN was established in 2005 by a donation from the Danish National Research Foundation. The research center combines the expertise from research groups specializing in solid- and liquid-state NMR spectroscopy, organic chemistry, protein chemistry, and biophysics. In 2010, the grant from the Danish National Research Foundation was extended by 5 years, with new the new focus to use the structural and functional insight towards biological intervention.

The center is directed by Prof. Niels Chr. Nielsen, who is also director of iNANO.